Mitochondrial Health Ratings
87 interventions — foods, drugs, supplements and lifestyle pillars like sleep, exercise, fasting, sauna and light — each graded for evidence, benefit and safety, and linked to the research. The honest, filterable database I wish existed. This is the one to start with.
Explore the ratings →graded
01Everything else, at a glance
Everything here in one glance — pick a door. New? The 5-minute VDAC1 primer is the gentlest start.
Research News
Recent mitochondria & VDAC1 research in plain words, always linked to the source.
Mito-Medicine Companies
A filterable watchlist of who's actually building mitochondrial medicine.
Clinical Trials
Mito-drug trials linked straight to their ClinicalTrials.gov records.
The VDAC1 Gene & Expression
The gene, its 283-amino-acid protein, and where in the body it's switched on.
VDAC1 Disease Body Map
Where VDAC1 goes wrong across the body — each organ linked to a key paper.
VDAC1 & Mitochondria Resources
The reviews, databases and labs I keep coming back to.
About — the mission
PSEN1 carrier, x-tosis co-founder, full-time mitochondria nerd.
02Fresh off the notebook
The latest bits. Full archive lives in news.
In septic T cells, VDAC1 oligomers open a pore that leaks mtDNA and drives inflammation — and VBIT-12 shuts it down
A Shanghai team watched VDAC1 clump up, leak mtDNA, and trip the cGAS–STING alarm in immune cells — and calmed the whole thing down with the oligomerization blocker VBIT-12.
the full story →→ Ren et al., Cell Signalling 2026 · doi.org/10.1016/j.cellsig.2026.112642
A mitochondria-targeting nanozyme restarts mitophagy in cartilage and switches off mtDNA-driven inflammation in osteoarthritis
Bioengineers at Shanghai Ninth People's Hospital built a mitochondria-targeting nanozyme that mops up damage in cartilage cells, restarts mitophagy, and shuts down the mtDNA→cGAS/STING inflammation loop in osteoarthritis.
read →Mendelian randomization flags specific mitochondrial genes as likely causal in acute and chronic kidney disease
A Sichuan group cross-referenced the whole MitoCarta gene inventory against genetics of acute and chronic kidney disease and pulled out a handful of mitochondrial genes that look causal.
read →03VDAC1 in 3D
The actual crystal structure of human VDAC1 (PDB 2JK4) — grab it and spin. Nineteen β-strands rolled into a barrel, N-terminal helix tucked inside. (Needs internet to load the atoms.)